ZYNYZ is a medicine that may treat a certain type of skin cancer by working with your immune system. ZYNYZ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.
Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:
Hormone gland problems
Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with ZYNYZ. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include:
Infusion reaction that can sometimes be severe. Signs and symptoms of infusion reactions may include:
ZYNYZ is a prescription medicine used to treat a type of skin cancer called Merkel cell carcinoma in adults. ZYNYZ may be used to treat your skin cancer when it has spread or returned.
It is not known if ZYNYZ is safe and effective in children.
ZYNYZ was evaluated in a clinical study in people with Merkel cell carcinoma. The initial assessment that led to the approval of ZYNYZ included 65 people who had Merkel cell carcinoma that had spread or returned. Some people in the study had surgery or radiation for their condition before treatment with ZYNYZ. None of the 65 people in the initial assessment received prior therapies like chemotherapy.
The study measured:
*Disappearance of all signs of cancer in response to treatment does not always mean the cancer has been cured.
Before you receive ZYNYZ, tell your healthcare provider about all of your medical conditions, including if you:
Females who are able to become pregnant:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Your healthcare provider will give you ZYNYZ into your vein through an intravenous (IV) line over 30 minutes. ZYNYZ is usually given every 4 weeks.
Your healthcare provider will decide how many treatments you will need.
Your healthcare provider will do blood tests to check you for side effects.
If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment.
ZYNYZ can cause serious side effects. See “What is the most important information I should know about ZYNYZ?”
The most common side effects of ZYNYZ include:
These are not all the possible side effects of ZYNYZ. Call your doctor for medical advice about side effects.
General information about the safe and effective use of ZYNYZ.
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. If you would like more information about ZYNYZ, talk with your healthcare provider. You can ask your healthcare provider for information about ZYNYZ that is written for health professionals.
You may also report side effects to Incyte Medical Information at 1-855-463-3463.
At IncyteCARES, our mission is to help eligible patients access their prescribed Incyte medication and to offer information and resources that provide extra support during treatment. Our team is available by phone every weekday.