What to expect during treatment

How ZYNYZ is administered

ZYNYZ is administered at your doctor’s office, in an infusion clinic, or in a hospital setting. 

IV bag labeled "500 mg" icon

ZYNYZ is given directly into your vein through an intravenous, or IV, line

Timer icon showing "30 minutes"

ZYNYZ is delivered as a 30-minute infusion

Calendar icon showing "every 4 weeks"

Treatment with ZYNYZ is given every 4 weeks

Your doctor will monitor your progress and do blood tests to check for side effects. Tell your doctor during these visits about any side effects you may be experiencing.

Treatment with ZYNYZ + chemotherapy

For people whose SCAC has returned and cannot be removed by surgery or has spread

You'll start your treatment with ZYNYZ + chemotherapy. Your doctor will determine how long this treatment lasts. Then, you may continue with ZYNYZ alone. ZYNYZ is administered for up to 1 year, or until your disease worsens or side effects become too difficult to tolerate.

Treatment with ZYNYZ alone

For people whose SCAC has returned or spread and who have received platinum-based chemotherapy and it did not work, is no longer working, or you could not tolerate it

ZYNYZ is administered for up to 2 years, or until your disease worsens or side effects become too difficult to tolerate.

Your doctor will talk to you in more detail about your specific treatment schedule. If you miss any appointments, call your doctor as soon as possible to reschedule your appointment.

Image of ZYNYZ patient brochure

Download the Patient Brochure for helpful information about treatment with ZYNYZ. You’ll also find additional support and resources that may help you on your journey.

Patient BrochureSupport & Resources

Frequently asked questions

Wear comfortable clothing that allows easy access to an IV, such as T-shirts, zip-ups, or button-downs. Be sure to eat well, stay hydrated, and get a good night's sleep before treatment. Arrive prepared with any questions or concerns you may have.

Many patients like to bring friends or family to keep them company. Some other things you might want to bring with you:

  • A book or another low-effort activity to keep you busy
  • A blanket
  • A water bottle
  • Snacks

Infusion times can vary during the first phase of treatment with ZYNYZ + chemotherapy. Your doctor will tell you for how long you can expect to receive treatment.

During the second phase of treatment, where you will only be receiving ZYNYZ, the infusion should take about 30 minutes.

At each of your appointments, you'll receive treatment through an intravenous (IV) line. This will include ZYNYZ + chemotherapy (in their own IV lines), or ZYNYZ alone. 

ZYNYZ is administered at your doctor's office, in an infusion clinic, or in a hospital setting. You should discuss with your doctor what the best place for you will be.

With chemotherapy (carboplatin + paclitaxel), the most common side effects of ZYNYZ included tiredness; numbness, pain, tingling, or burning in your hands or feet; nausea; hair loss; diarrhea; muscle and bone pain; constipation; bleeding; rash; vomiting; decreased appetite; itching; stomach-area pain.

When used alone, the most common side effects of ZYNYZ included tiredness, muscle and bone pain, diarrhea, infection, rectal or genital-area pain, bleeding, urinary tract infection (UTI), rash, nausea, loss of appetite, constipation, stomach-area pain, shortness of breath, fever, vomiting, cough, itching, low levels of thyroid hormone, headache, decreased weight.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Incyte Medical Information at 1-855-463-3463.

If you have questions or concerns about ZYNYZ, your diagnosis, or your treatments, you should discuss them with your care team. You can also call IncyteCARES at 1-855-452-5234.

There are no foods that you need to avoid with ZYNYZ.

Downloadable resources and advocacy groups are available to support you, and you can access them here.

Possible side effects of ZYNYZ

Tell your care team about any side effects you experience while on treatment. Depending on the severity of the side effects, your doctor may skip a dose of ZYNYZ or recommend that you stop taking it. It is not recommended that you skip an infusion appointment without speaking with your doctor.

Please continue scrolling to view Important Safety Information for ZYNYZ.

What is ZYNYZ?

ZYNYZ is a prescription medicine used to treat adults with:

  • a type of anal cancer called squamous cell carcinoma of the anal canal (SCAC).
    • ZYNYZ may be used in combination with the chemotherapy medicines carboplatin and paclitaxel as your first treatment when your anal cancer:
      • has returned and cannot be removed by surgery, or
      • has spread.
    • ZYNYZ may be used alone when your anal cancer:
      • has returned or has spread and
      • you have received chemotherapy that contains platinum, and it did not work, is no longer working, or you could not tolerate it.

It is not known if ZYNYZ is safe and effective in children.

Important Safety Information

What is the most important information I should know about ZYNYZ?

ZYNYZ is a medicine that may treat certain types of cancers by working with your immune system. ZYNYZ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

Call or see your doctor right away if you develop any new or worsening signs or symptoms, including:

Lung problems: cough, shortness of breath, chest pain

Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; severe stomach-area (abdomen) pain or tenderness

Liver problems: yellowing of your skin or the whites of your eyes; severe nausea or vomiting; pain on the right side of your stomach area (abdomen); dark urine (tea colored); bleeding or bruising more easily than normal

Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, loss of appetite

Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in your mouth or nose, throat, or genital area; fever or flu-like symptoms; swollen lymph nodes

Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with ZYNYZ. Call or see your doctor right away for any new or worsening signs or symptoms, which may include:

  • chest pain, irregular heartbeat, shortness of breath, or swelling of ankles
  • confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs
  • double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight
  • persistent or severe muscle pain or weakness, muscle cramps
  • low red blood cells, bruising

Infusion reactions that can sometimes be severe. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, back or neck pain.

Rejection of a transplanted organ or tissue. Your doctor should tell you what signs and symptoms you should report and monitor you, depending on the type of organ or tissue transplant that you have had.

Complications, including graft-versus-host disease, in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with ZYNYZ. Your doctor will monitor you for these complications.

Getting medical treatment right away may help keep these problems from becoming more serious. Your doctor will check you for these problems during your treatment with ZYNYZ. Your doctor may treat you with corticosteroid or hormone replacement medicines and may also need to delay or completely stop treatment with ZYNYZ if you have severe side effects.

Before you receive ZYNYZ, tell your doctor about all of your medical conditions, including if you:

  • have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus
  • have received an organ or tissue transplant, including corneal transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. ZYNYZ can harm your unborn baby.

Females who are able to become pregnant:

  • Your doctor should do a pregnancy test before you start treatment with ZYNYZ.
  • You should use an effective method of birth control during your treatment and for 4 months after your last dose of ZYNYZ. Talk to your doctor about birth control methods that you can use during this time.
  • Tell your doctor right away if you become pregnant or think you may be pregnant during treatment with ZYNYZ.
  • are breastfeeding or plan to breastfeed. It is not known if ZYNYZ passes into your breast milk. Do not breastfeed during treatment and for 4 months after your last dose of ZYNYZ.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of ZYNYZ when given with the chemotherapy medicines carboplatin and paclitaxel in people with SCAC include tiredness; numbness, pain, tingling, or burning in your hands or feet; nausea; hair loss; diarrhea; muscle and bone pain; constipation; bleeding; rash; vomiting; decreased appetite; itching; stomach-area pain.

The most common side effects of ZYNYZ when used alone in people with SCAC include tiredness, muscle and bone pain, diarrhea, infection, rectal or genital-area pain, urinary tract infection (UTI), rash, nausea, loss of appetite, constipation, stomach-area pain, shortness of breath, fever, vomiting, cough, itching, low levels of thyroid hormone, headache, decreased weight.

These are not all the possible side effects of ZYNYZ. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

General information about the safe and effective use of ZYNYZ

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. If you would like more information about ZYNYZ, talk with your doctor. You can ask your doctor for information about ZYNYZ that is written for health professionals.

Please see the Full Prescribing Information, including the Medication Guide, for ZYNYZ.

 
 

What is ZYNYZ?

ZYNYZ is a prescription medicine used to treat adults with:

  • a type of anal cancer called squamous cell carcinoma of the anal canal (SCAC).
    • ZYNYZ may be used in combination with the chemotherapy medicines carboplatin and paclitaxel as your first treatment when your anal cancer:
      • has returned and cannot be removed by surgery, or
      • has spread.
    • ZYNYZ may be used alone when your anal cancer:
      • has returned or has spread and
      • you have received chemotherapy that contains platinum, and it did not work, is no longer working, or you could not tolerate it.

It is not known if ZYNYZ is safe and effective in children.

Important Safety Information

What is the most important information I should know about ZYNYZ?

ZYNYZ is a medicine that may treat certain types of cancers by working with your immune system. ZYNYZ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

Call or see your doctor right away if you develop any new or worsening signs or symptoms, including:

Lung problems: cough, shortness of breath, chest pain

Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; severe stomach-area (abdomen) pain or tenderness

Liver problems: yellowing of your skin or the whites of your eyes; severe nausea or vomiting; pain on the right side of your stomach area (abdomen); dark urine (tea colored); bleeding or bruising more easily than normal

Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, loss of appetite

Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in your mouth or nose, throat, or genital area; fever or flu-like symptoms; swollen lymph nodes

Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with ZYNYZ. Call or see your doctor right away for any new or worsening signs or symptoms, which may include:

  • chest pain, irregular heartbeat, shortness of breath, or swelling of ankles
  • confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs
  • double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight
  • persistent or severe muscle pain or weakness, muscle cramps
  • low red blood cells, bruising

Infusion reactions that can sometimes be severe. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, back or neck pain.

Rejection of a transplanted organ or tissue. Your doctor should tell you what signs and symptoms you should report and monitor you, depending on the type of organ or tissue transplant that you have had.

Complications, including graft-versus-host disease, in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with ZYNYZ. Your doctor will monitor you for these complications.

Getting medical treatment right away may help keep these problems from becoming more serious. Your doctor will check you for these problems during your treatment with ZYNYZ. Your doctor may treat you with corticosteroid or hormone replacement medicines and may also need to delay or completely stop treatment with ZYNYZ if you have severe side effects.

Before you receive ZYNYZ, tell your doctor about all of your medical conditions, including if you:

  • have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus
  • have received an organ or tissue transplant, including corneal transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. ZYNYZ can harm your unborn baby.

Females who are able to become pregnant:

  • Your doctor should do a pregnancy test before you start treatment with ZYNYZ.
  • You should use an effective method of birth control during your treatment and for 4 months after your last dose of ZYNYZ. Talk to your doctor about birth control methods that you can use during this time.
  • Tell your doctor right away if you become pregnant or think you may be pregnant during treatment with ZYNYZ.
  • are breastfeeding or plan to breastfeed. It is not known if ZYNYZ passes into your breast milk. Do not breastfeed during treatment and for 4 months after your last dose of ZYNYZ.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of ZYNYZ when given with the chemotherapy medicines carboplatin and paclitaxel in people with SCAC include tiredness; numbness, pain, tingling, or burning in your hands or feet; nausea; hair loss; diarrhea; muscle and bone pain; constipation; bleeding; rash; vomiting; decreased appetite; itching; stomach-area pain.

The most common side effects of ZYNYZ when used alone in people with SCAC include tiredness, muscle and bone pain, diarrhea, infection, rectal or genital-area pain, urinary tract infection (UTI), rash, nausea, loss of appetite, constipation, stomach-area pain, shortness of breath, fever, vomiting, cough, itching, low levels of thyroid hormone, headache, decreased weight.

These are not all the possible side effects of ZYNYZ. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

General information about the safe and effective use of ZYNYZ

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. If you would like more information about ZYNYZ, talk with your doctor. You can ask your doctor for information about ZYNYZ that is written for health professionals.

Please see the Full Prescribing Information, including the Medication Guide, for ZYNYZ.